1-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidine → Tert-butyl 4-(5-chloro-1-(4-cyano-3-fluorophenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate

HRID 2125246Notes

Reaction equation

HRID 2125246 reaction equation
[CH2:47]([c:48]1[cH:49][n:50][c:51]([N:52]2[CH2:53][CH2:54][CH:55]([CH2:56][S:57]([O-:58])(=[O:59])=[O:60])[CH2:61][CH2:62]2)[n:63][cH:64]1)[CH2:65][CH3:66].[CH3:29][S:30]([O:31][CH:34]1[CH2:35][CH2:36][N:37]([C:40](=[O:41])[O:42][C:43]([CH3:44])([CH3:45])[CH3:46])[CH2:38][CH2:39]1)(=[O:32])=[O:33].[Cl:1][c:2]1[c:3]([OH:18])[cH:4][c:5](=[O:17])[n:6](-[c:8]2[cH:9][c:10]([F:16])[c:11]([C:12]#[N:13])[cH:14][cH:15]2)[cH:7]1.[OH:19][c:20]1[c:21]([C:22]#[N:23])[cH:24][nH:25][c:26](=[O:27])[cH:28]1>>[Cl:1][c:2]1[c:3]([O:18][CH:34]2[CH2:35][CH2:36][N:37]([C:40](=[O:41])[O:42][C:43]([CH3:44])([CH3:45])[CH3:46])[CH2:38][CH2:39]2)[cH:4][c:5](=[O:17])[n:6](-[c:8]2[cH:9][c:10]([F:16])[c:11]([C:12]#[N:13])[cH:14][cH:15]2)[cH:7]1

Participants

5

Reactant 4

HCID 41848691-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidineHCID 547063254,6-DihydroxynicotinonitrileHCID 673665324-(5-chloro-4-hydroxy-2-oxopyridin-1(2H)-yl)-2-fluorobenzonitrileHCID 866580301-(5-Propylpyrimidin-2-yl)piperidin-4-ylmethanesulfonate

Product 1

HCID 57468467Tert-butyl 4-(5-chloro-1-(4-cyano-3-fluorophenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-72aa915857974131bc28ee21af15a950
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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