Methanol → tert-Butyl {(S)-1-methyl-2-oxo-2-[(S)-pyrrolidin-3-ylamino]ethyl}carbamate

HRID 212575Notes

Reaction equation

HRID 212575 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH:10]([NH:13][C:14]([CH:15]([CH3:16])[NH:17][C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:25])[CH2:11][CH2:12]1.[CH3:29][OH:30].[H:27][H:28].[OH-:31].[OH-:33].[OH2:26].[Pd+2:32]>>[NH:8]1[CH2:9][CH:10]([NH:13][C:14]([CH:15]([CH3:16])[NH:17][C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:25])[CH2:11][CH2:12]1

Participants

7

Reactant 6

HCID 887MethanolHCID 961Hydroxide2×HCID 962WaterHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 14555447HCID 14555447, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 14555449tert-Butyl {(S)-1-methyl-2-oxo-2-[(S)-pyrrolidin-3-ylamino]ethyl}carbamate

Sources & evidence

ORD record
ord-ca8ddce69bde44c68f04d3e12353139b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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