Pyridine → Methyl 2-(3-(tert-butoxycarbonyl)phenyl)-6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)nicotinate

HRID 2125802Notes

Reaction equation

HRID 2125802 reaction equation
[Cl:48][CH2:49][Cl:50].[F:25][C:26]1([F:41])[O:27][c:28]2[c:29]([cH:31][cH:32][c:33]([C:35]3([C:38](=[O:39])[Cl:40])[CH2:36][CH2:37]3)[cH:34]2)[O:30]1.[NH2:1][c:2]1[n:3][c:4](-[c:12]2[cH:13][c:14]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[cH:15][cH:16][cH:17]2)[c:5]([C:6](=[O:7])[O:8][CH3:9])[cH:10][cH:11]1.[cH:42]1[cH:43][cH:44][n:45][cH:46][cH:47]1>>[NH:1]([c:2]1[n:3][c:4](-[c:12]2[cH:13][c:14]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[cH:15][cH:16][cH:17]2)[c:5]([C:6](=[O:7])[O:8][CH3:9])[cH:10][cH:11]1)[C:38]([C:35]1([c:33]2[cH:32][cH:31][c:29]3[c:28]([cH:34]2)[O:27][C:26]([F:25])([F:41])[O:30]3)[CH2:36][CH2:37]1)=[O:39]

Participants

5

Reactant 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 575168501-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl chlorideHCID 59166112Methyl 6-amino-2-(3-(tert-butoxycarbonyl)phenyl)nicotinate

Product 1

HCID 59166109Methyl 2-(3-(tert-butoxycarbonyl)phenyl)-6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)nicotinate

Sources & evidence

ORD record
ord-6fb8a4565c0e4f2d90fc70674ee34e1a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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