HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloride methanol → 4-Chloro-5-hydroxy-7-iodoisoindolinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Reactant | 4-Chloro-5-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone | HCID 68493984 | — |
| Product | 4-Chloro-5-hydroxy-7-iodoisoindolinone | HCID 68489249 | 58% |
Reaction Steps
In a similar manner to Step 6 of Example 139, 4-chloro-5-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (97.1 mg, 0.206 mmol) was treated with 10% hydrogen chloride-methanol solution (3 mL), followed by purification by slurry using diisopropylether to obtain 4-chloro-5-hydroxy-7-iodoisoindolinone (36.9 mg, yield 58%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745641B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-9e6bd2567c9c46e48a78b830e9111924 |
| Source note | uspto-grants-2010_06 |