反应详情

4-Methoxymethoxy-5-dimethoxymethyl-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (490 mg, 0.929 mmol) was dissolved in methanol (10 mL), and the solution was treated with 10% hydrogen chloride-methanol solution (5 mL), followed by stirring at room temperature for 3 hours. The solvent was evaporated under reduced pressure and the residue was dissolved in acetonitrile (5 mL). The solution was added with 1 mol/L hydrochloric acid (5 mL) and stirred at room temperature for 1 hour. The precipitated solid was collected by filtration and washed with water, followed by drying under reduced pressure to obtain 4-hydroxy-5-formyl-3-methoxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (329 mg, yield 79%).

1. customThe solvent was evaporated under reduced pressure
2. dissolutionthe residue was dissolved in acetonitrile (5 mL)
3. additionThe solution was added with 1 mol/L hydrochloric acid (5 mL)
4. stirringstirred at room temperature for 1 hour
5. filtrationThe precipitated solid was collected by filtration
6. washwashed with water
7. customby drying under reduced pressure