1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 68492049、化合物

関与物質

反応手順

In a similar manner to Step 11 of Example 137, 3-methoxymethoxy-4-methoxybenzoic acid (6.41 g, 30.2 mmol) was dissolved in DMF (100 mL), and the solution was treated with EDCI (5.75 g, 30.0 mmol), HOBT monohydrate (4.05 g, 30.0 mmol) and cumylamine (8.63 mL, 60.0 mmol). The reaction mixture was added with water. The precipitated solid was collected by filtration and washed with water, followed by drying under reduced pressure to obtain 3-methoxymethoxy-4-methoxy-N-(1-methyl-1-phenylethyl)benzamide (7.89 g, yield 80%).

情報源と証拠