2-(7-Amino-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-acetamide → 2-{7-[5-Fluoro-4-(2-methoxy-4-morpholin-4-yl-phenylamino)-pyrimidin-2-ylamino]-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl}-acetamide

HRID 2126881Notes

Reaction equation

HRID 2126881 reaction equation
[Cl:19][c:20]1[n:21][cH:22][c:23]([F:41])[c:24]([NH:26][c:27]2[c:28]([O:39][CH3:40])[cH:29][c:30]([N:33]3[CH2:34][CH2:35][O:36][CH2:37][CH2:38]3)[cH:31][cH:32]2)[n:25]1.[NH2:1][c:2]1[cH:3][c:4]2[c:5]([cH:15][c:16]1[O:17][CH3:18])[CH2:6][CH2:7][N:8]([CH2:11][C:12](=[O:13])[NH2:14])[CH2:9][CH2:10]2>>[NH:1]([c:2]1[cH:3][c:4]2[c:5]([cH:15][c:16]1[O:17][CH3:18])[CH2:6][CH2:7][N:8]([CH2:11][C:12](=[O:13])[NH2:14])[CH2:9][CH2:10]2)[c:20]1[n:21][cH:22][c:23]([F:41])[c:24]([NH:26][c:27]2[c:28]([O:39][CH3:40])[cH:29][c:30]([N:33]3[CH2:34][CH2:35][O:36][CH2:37][CH2:38]3)[cH:31][cH:32]2)[n:25]1

Participants

3

Reactant 2

HCID 667114642-(7-Amino-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-acetamideHCID 86633934(2-Chloro-5-fluoro-pyrimidin-4-yl)-(2-methoxy-4-morpholin-4-yl-phenyl)-amine

Product 1

HCID 668303102-{7-[5-Fluoro-4-(2-methoxy-4-morpholin-4-yl-phenylamino)-pyrimidin-2-ylamino]-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl}-acetamide

Sources & evidence

ORD record
ord-a0784068917f4bdabff6c2bb3baa329d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

Loading…