Methanol → N-(1,2,3,3a,4,5,6,6a-octahydrocyclopenta[c]pyrrol-4-yl)-N-cyclopropyl-3-(trifluoromethyl)benzenesulfonamide

HRID 2126897Notes

Reaction equation

HRID 2126897 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH:10]2[CH:11]([CH2:12]1)[CH:13]([N:16]([S:17](=[O:18])(=[O:19])[c:20]1[cH:21][c:22]([C:26]([F:27])([F:28])[F:29])[cH:23][cH:24][cH:25]1)[CH:30]1[CH2:31][CH2:32]1)[CH2:14][CH2:15]2.[CH3:36][OH:37].[OH-:33].[OH-:35].[Pd+2:34]>>[NH:8]1[CH2:9][CH:10]2[CH:11]([CH2:12]1)[CH:13]([N:16]([S:17](=[O:18])(=[O:19])[c:20]1[cH:21][c:22]([C:26]([F:27])([F:28])[F:29])[cH:23][cH:24][cH:25]1)[CH:30]1[CH2:31][CH2:32]1)[CH2:14][CH2:15]2

Participants

5

Reactant 4

HCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 68413615N-(2-benzyl-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-4-yl)-N-cyclopropyl-3-(trifluoromethyl)benzenesulfonamide

Product 1

HCID 66590636N-(1,2,3,3a,4,5,6,6a-octahydrocyclopenta[c]pyrrol-4-yl)-N-cyclopropyl-3-(trifluoromethyl)benzenesulfonamide

Sources & evidence

ORD record
ord-8367efc65d1d4e43847fc90554a2add1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

Loading…