Dimethyl-1,3-thiazole-5-carboxylic acid → 2,4-Dimethyl-N-(3-{1-methyl-2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-1,3-thiazole-5-carboxamide

HRID 2127041Notes

Reaction equation

HRID 2127041 reaction equation
[CH3:1][CH:2]([CH2:3][N:4]1[CH2:5][CH2:6][N:7]([c:10]2[c:11]3[cH:12][cH:13][c:14]([CH3:20])[n:15][c:16]3[cH:17][cH:18][cH:19]2)[CH2:8][CH2:9]1)[c:21]1[cH:22][c:23]([NH2:24])[cH:25][cH:26][cH:27]1.[CH3:28][c:29]1[s:30][c:31]([C:35](=[O:36])[OH:37])[c:32]([CH3:34])[n:33]1>>[CH3:1][CH:2]([CH2:3][N:4]1[CH2:5][CH2:6][N:7]([c:10]2[c:11]3[cH:12][cH:13][c:14]([CH3:20])[n:15][c:16]3[cH:17][cH:18][cH:19]2)[CH2:8][CH2:9]1)[c:21]1[cH:22][c:23]([NH:24][C:35]([c:31]2[s:30][c:29]([CH3:28])[n:33][c:32]2[CH3:34])=[O:36])[cH:25][cH:26][cH:27]1

Participants

3

Reactant 2

HCID 736488Dimethyl-1,3-thiazole-5-carboxylic acidHCID 574443353-{1-Methyl-2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline

Product 1

HCID 574783562,4-Dimethyl-N-(3-{1-methyl-2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-1,3-thiazole-5-carboxamide

Sources & evidence

ORD record
ord-43d8ed49f6b94c02871b6bb89009b715
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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