Ammonia → tert-Butyl 4-amino-4-(aminomethyl)piperidine-1-carboxylate

HRID 2127202Notes

Reaction equation

HRID 2127202 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([NH:14][C:15](=[O:16])[C:17]([F:18])([F:19])[F:20])([CH2:21][NH2:22])[CH2:12][CH2:13]1.[CH3:24][OH:25].[NH3:23]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([NH2:14])([CH2:21][NH2:22])[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 887MethanolHCID 866419114-Aminomethyl-4-(2,2,2-trifluoro-acetylamino)-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 22975818tert-Butyl 4-amino-4-(aminomethyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-9e46deb241fb494a816956a5b7bbbd3e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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