3,4-Difluoroaniline → 1-Boc-4-[(3,4-difluorophenyl)amino]-piperidine

HRID 2127314Notes

Reaction equation

HRID 2127314 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11](=[O:14])[CH2:12][CH2:13]1.[F:15][c:16]1[cH:17][c:18]([NH2:19])[cH:20][cH:21][c:22]1[F:23]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([NH:19][c:18]2[cH:17][c:16]([F:15])[c:22]([F:23])[cH:21][cH:20]2)[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 774693,4-DifluoroanilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 225580331-Boc-4-[(3,4-difluorophenyl)amino]-piperidine

Sources & evidence

ORD record
ord-dfd1962dde0b49c48ee1bcaada15965b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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