Carbonate Ion → 5-Cyclopropyl-6-(4-fluoro-benzyl)-pyridine-2-carbonitrile

HRID 2127355Notes

Reaction equation

HRID 2127355 reaction equation
[Br:1][CH2:2][c:3]1[c:4]([CH:11]2[CH2:12][CH2:13]2)[cH:5][cH:6][c:7]([C:9]#[N:10])[n:8]1.[C:25](=[O:26])([O-:27])[O-:28].[Cs+:29].[Cs+:30].[F:14][c:15]1[cH:16][cH:17][c:18]([CH2:19][B:20]([OH:21])[OH:22])[cH:23][cH:24]1>>[CH2:2]([c:3]1[c:4]([CH:11]2[CH2:12][CH2:13]2)[cH:5][cH:6][c:7]([C:9]#[N:10])[n:8]1)[c:18]1[cH:17][cH:16][c:15]([F:14])[cH:24][cH:23]1

Participants

5

Reactant 4

HCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 45090593(4-Fluorobenzyl)boronic acidHCID 866747706-Bromomethyl-5-cyclopropyl-pyridine-2-carbonitrile

Product 1

HCID 710874595-Cyclopropyl-6-(4-fluoro-benzyl)-pyridine-2-carbonitrile

Sources & evidence

ORD record
ord-605cd02ba9f643e4abc4700a9dfebc43
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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