1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 3-methoxymethoxy-4-methyl-N-(1-methyl-1-phenylethyl)benzamide

Participants

Reaction Steps

In a similar manner to Step 1 of Example 137, 3-methoxymethoxy-4-methylbenzoic acid (2.69 g) was dissolved in DMF (53 mL), and the solution was treated with EDCI (5.04 g, 26.3 mmol), HOBT monohydrate (2.01 g, 13.1 mmol) and cumylamine (3.80 mL, 26.4 mmol), followed by purification by slurry using hexane to obtain 3-methoxymethoxy-4-methyl-N-(1-methyl-1-phenylethyl)benzamide (3.42 g, yield 83%, 2 steps).

Provenance & Evidence