7-Methyl-6-chlorochromene → 6-chloro-7-(thien-2-ylmethyl)-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid
Reaction equation
[CH3:27][c:28]1[cH:29][c:30]2[c:31]([cH:36][c:37]1[Cl:38])[CH:32]=[CH:33][CH2:34][O:35]2.[Cl:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][c:11]1[CH2:12][c:13]1[s:14][cH:15][cH:16][cH:17]1)[O:8][CH:7]([C:18]([F:19])([F:20])[F:21])[C:6]([C:22](=[O:23])[O:24][CH2:25][CH3:26])=[CH:5]2>>[Cl:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][c:11]1[CH2:12][c:13]1[s:14][cH:15][cH:16][cH:17]1)[O:8][CH:7]([C:18]([F:19])([F:20])[F:21])[C:6]([C:22](=[O:23])[OH:24])=[CH:5]2Participants
3
Sources & evidence
- ORD record
- ord-2a7f2258329449bb9dfe47f200a8bf01
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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