Methanol → 8-Benzyl-2-oxo-1-phenyl-8-azabicyclo[3.2.1]octane-6-carbonitrile

HRID 2127780Notes

Reaction equation

HRID 2127780 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[C:9]2([c:19]3[cH:20][cH:21][cH:22][cH:23][cH:24]3)[C:10](=[O:18])[CH:11]=[CH:12][CH:13]1[CH:14]([C:16]#[N:17])[CH2:15]2.[CH3:25][OH:26].[OH-:27].[OH-:29].[Pd+2:28]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[C:9]2([c:19]3[cH:20][cH:21][cH:22][cH:23][cH:24]3)[C:10](=[O:18])[CH2:11][CH2:12][CH:13]1[CH:14]([C:16]#[N:17])[CH2:15]2

Participants

5

Reactant 4

HCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 698894168-Benzyl-2-oxo-1-phenyl-8-azabicyclo[3.2.1]oct-3-ene-6-carbonitrile

Product 1

HCID 696846028-Benzyl-2-oxo-1-phenyl-8-azabicyclo[3.2.1]octane-6-carbonitrile

Sources & evidence

ORD record
ord-560ae7e88e0943039201e076efd50175
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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