Diethyl Ether → 1-{6-[(Tert-butyldimethylsilanyl)ethynyl]-5-fluoropyridin-3-yl}-4-methylcyclohexanol
Reaction equation
[Br:6][c:7]1[cH:8][c:9]([F:22])[c:10]([C:13]#[C:14][Si:15]([CH3:16])([CH3:17])[C:18]([CH3:19])([CH3:20])[CH3:21])[n:11][cH:12]1.[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH3:23][CH:24]1[CH2:25][CH2:26][C:27](=[O:30])[CH2:28][CH2:29]1.[CH3:31][CH2:32][O:33][CH2:34][CH3:35]>>[c:7]1([C:27]2([OH:30])[CH2:26][CH2:25][CH:24]([CH3:23])[CH2:29][CH2:28]2)[cH:8][c:9]([F:22])[c:10]([C:13]#[C:14][Si:15]([CH3:16])([CH3:17])[C:18]([CH3:19])([CH3:20])[CH3:21])[n:11][cH:12]1Participants
5
Sources & evidence
- ORD record
- ord-79509cfbc8b34557ab88af73226f7f32
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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