HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Chlorophenacyl bromide → 5-(4-Chlorophenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Chlorophenacyl bromide | HCID 68303 | — |
| Reactant | O-methyl hydrazinecarbothioate | HCID 10171237 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 5-(4-Chlorophenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one | HCID 329473 | 48.4% |
Reaction Steps
A mixture of 2-bromo-p-chloroacetophenone (9.16 g), methoxythiocarbonylhydrazine (13.0 g) and acetonitrile (75 ml) was refluxed overnight and then cooled and filtered. The light yellow solid was washed with hexane and dried yielding 5-(4-chlorophenyl)-3H,6H-1,3,4-thiadiazin-2-one (4.3 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05728698 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-a3d67c3bad7c44c29b9bc8727026575d |
| Source note | uspto-grants-1998_03 |