4-(Trifluoromethyl)aniline → 1-Boc-4-(4-Trifluoromethyl-phenylamino)-piperidine

HRID 2128030Notes

Reaction equation

HRID 2128030 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11](=[O:14])[CH2:12][CH2:13]1.[F:15][C:16]([c:17]1[cH:18][cH:19][c:20]([NH2:21])[cH:22][cH:23]1)([F:24])[F:25]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([NH:21][c:20]2[cH:19][cH:18][c:17]([C:16]([F:15])([F:24])[F:25])[cH:23][cH:22]2)[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 99644-(Trifluoromethyl)anilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 220291421-Boc-4-(4-Trifluoromethyl-phenylamino)-piperidine

Sources & evidence

ORD record
ord-56a11019e6184dbe884757dd07723e0f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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