4-Piperidinamine → N-{3-[2-(4-amino-1-piperidinyl)-8-(2,6-difluorophenyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylphenyl}-3-thiophenecarboxamide

HRID 2128617Notes

Reaction equation

HRID 2128617 reaction equation
[F:1][c:2]1[c:3](-[n:9]2[c:10](=[O:38])[cH:11][cH:12][c:13]3[c:14]2[n:15][c:16]([S:34]([CH3:35])(=[O:36])=[O:37])[n:17][c:18]3-[c:19]2[cH:20][c:21]([NH:26][C:27](=[O:28])[c:29]3[cH:30][s:31][cH:32][cH:33]3)[cH:22][cH:23][c:24]2[CH3:25])[c:4]([F:8])[cH:5][cH:6][cH:7]1.[NH:39]1[CH2:40][CH2:41][CH:42]([NH2:45])[CH2:43][CH2:44]1>>[F:1][c:2]1[c:3](-[n:9]2[c:10](=[O:38])[cH:11][cH:12][c:13]3[c:14]2[n:15][c:16]([N:39]2[CH2:40][CH2:41][CH:42]([NH2:45])[CH2:43][CH2:44]2)[n:17][c:18]3-[c:19]2[cH:20][c:21]([NH:26][C:27](=[O:28])[c:29]3[cH:30][s:31][cH:32][cH:33]3)[cH:22][cH:23][c:24]2[CH3:25])[c:4]([F:8])[cH:5][cH:6][cH:7]1

Participants

3

Reactant 2

HCID 4243614-PiperidinamineHCID 11947980HCID 11947980, compound

Product 1

HCID 11948023N-{3-[2-(4-amino-1-piperidinyl)-8-(2,6-difluorophenyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylphenyl}-3-thiophenecarboxamide

Sources & evidence

ORD record
ord-30fc1cbaf89b4faa9861ca38e2a1e70e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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