2-Methyl-6-(methylsulfonyl)pyridin-3-amine → tert-Butyl 4-(4-(2-methyl-6-(methylsulfonyl)pyridin-3-ylamino)-6H-pyrimido[5,4-b][1,4]oxazin-8(7H)-yl)piperidine-1-carboxylate

HRID 2128633Notes

Reaction equation

HRID 2128633 reaction equation
[CH3:1][c:2]1[n:3][c:4]([S:9](=[O:10])(=[O:11])[CH3:12])[cH:5][cH:6][c:7]1[NH2:8].[Cl:13][c:14]1[n:15][cH:16][n:17][c:18]2[c:19]1[O:20][CH2:21][CH2:22][N:23]2[CH:24]1[CH2:25][CH2:26][N:27]([C:30](=[O:31])[O:32][C:33]([CH3:34])([CH3:35])[CH3:36])[CH2:28][CH2:29]1>>[CH3:1][c:2]1[n:3][c:4]([S:9](=[O:10])(=[O:11])[CH3:12])[cH:5][cH:6][c:7]1[NH:8][c:14]1[n:15][cH:16][n:17][c:18]2[c:19]1[O:20][CH2:21][CH2:22][N:23]2[CH:24]1[CH2:25][CH2:26][N:27]([C:30](=[O:31])[O:32][C:33]([CH3:34])([CH3:35])[CH3:36])[CH2:28][CH2:29]1

Participants

3

Reactant 2

HCID 510505272-Methyl-6-(methylsulfonyl)pyridin-3-amineHCID 58293623tert-butyl 4-(4-chloro-6H-pyrimido[5,4-b][1,4]oxazin-8(7H)-yl)piperidine-1-carboxylate

Product 1

HCID 58293644tert-Butyl 4-(4-(2-methyl-6-(methylsulfonyl)pyridin-3-ylamino)-6H-pyrimido[5,4-b][1,4]oxazin-8(7H)-yl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-8c1e3d5781d342379e53ba6c030010c6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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