Hydrochloride methanol → HCID 86628304, compound

HRID 21288Notes

Reaction equation

HRID 21288 reaction equation
[CH3:1][S:2]([O:5][C:6]1[C:14]([O:15][CH3:16])=[CH:13][C:12]([C:17]2[N:18](C(OC(C)(C)C)=O)[C:19]3[C:24]([CH:25]=2)=[CH:23][CH:22]=[CH:21][CH:20]=3)=[C:11]2[C:7]=1[CH2:8][NH:9][C:10]2=[O:33])(=[O:4])=[O:3].[ClH:34].CO>CO>[ClH:34].[CH3:1][S:2]([O:5][C:6]1[C:14]([O:15][CH3:16])=[CH:13][C:12]([C:17]2[NH:18][C:19]3[C:24]([CH:25]=2)=[CH:23][CH:22]=[CH:21][CH:20]=3)=[C:11]2[C:7]=1[CH2:8][NH:9][C:10]2=[O:33])(=[O:3])=[O:4]

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 866283034-Methanesulfonyloxy-5-methoxy-7-(1-(tert-butoxycarbonyl)indol-2-yl)isoindolinone

Product 1

HCID 86628304HCID 86628304, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner to Step 2 of Example 8, 4-methanesulfonyloxy-5-methoxy-7-(1-(tert-butoxycarbonyl)indol-2-yl)isoindolinone (54.5 mg, 0.115 mmol) was dissolved in methanol (1.5 mL), and the solution was treated with 10% hydrogen chloride-methanol solution (1.5 mL). The precipitated solid was collected by filtration and washed with methanol, followed by drying under reduced pressure to obtain Compound 381 (31.0 mg, yield 72%).

Workup

  1. filtrationThe precipitated solid was collected by filtration
  2. washwashed with methanol
  3. customby drying under reduced pressure

Sources & evidence

ORD record
ord-c20e44ee039c453eb055cc2e09a43c98
Source dataset
uspto-grants-2010_06
Patent number
US07745641B2

Reaction notes

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