反应详情

In a similar manner to Step 2 of Example 8, 4-methanesulfonyloxy-5-methoxy-7-(1-(tert-butoxycarbonyl)indol-2-yl)isoindolinone (54.5 mg, 0.115 mmol) was dissolved in methanol (1.5 mL), and the solution was treated with 10% hydrogen chloride-methanol solution (1.5 mL). The precipitated solid was collected by filtration and washed with methanol, followed by drying under reduced pressure to obtain Compound 381 (31.0 mg, yield 72%).

1. filtrationThe precipitated solid was collected by filtration
2. washwashed with methanol
3. customby drying under reduced pressure