Ethyl 2-bromo-1,3-thiazole-4-carboxylate → tert-butyl 7-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]-3,4-dihydroisoquinoline-2(1H)-carboxylate
Reaction equation
[Br:27][c:28]1[s:29][cH:30][c:31]([C:33](=[O:34])[O:35][CH2:36][CH3:37])[n:32]1.[CH3:1][C:2]1([CH3:3])[C:4]([CH3:5])([CH3:6])[O:7][B:8]([c:9]2[cH:10][cH:11][c:12]3[c:17]([cH:18]2)[CH2:16][N:15]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:14][CH2:13]3)[O:26]1>>[c:9]1(-[c:28]2[s:29][cH:30][c:31]([C:33](=[O:34])[O:35][CH2:36][CH3:37])[n:32]2)[cH:10][cH:11][c:12]2[c:17]([cH:18]1)[CH2:16][N:15]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:14][CH2:13]2Participants
3
Sources & evidence
- ORD record
- ord-9c49cb62bae8424882dc5eb687602089
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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