Pyridine → N-{5-[5-(2-Chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

HRID 2129345Notes

Reaction equation

HRID 2129345 reaction equation
[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:17]3[cH:18][cH:19][c:20]([F:24])[c:21]([NH2:22])[cH:23]3)[n:10][c:11]([C:13]([CH3:14])([CH3:15])[CH3:16])[s:12]2)[n:7]1.[Cl:43][CH2:44][Cl:45].[F:31][c:32]1[c:33]([S:39](=[O:40])(=[O:41])[Cl:42])[c:34]([F:38])[cH:35][cH:36][cH:37]1.[cH:25]1[cH:26][cH:27][n:28][cH:29][cH:30]1>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:17]3[cH:18][cH:19][c:20]([F:24])[c:21]([NH:22][S:39]([c:33]4[c:32]([F:31])[cH:37][cH:36][cH:35][c:34]4[F:38])(=[O:40])=[O:41])[cH:23]3)[n:10][c:11]([C:13]([CH3:14])([CH3:15])[CH3:16])[s:12]2)[n:7]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 27342712,6-Difluorobenzenesulfonyl chlorideHCID 579897645-[5-(2-Chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluoroaniline

Product 1

HCID 86636578N-{5-[5-(2-Chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

Sources & evidence

ORD record
ord-23fb97986a434600b44a3a9c071311fe
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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