Toluene → N-{2-chloro-3-[2-(1,1-dimethylethyl)-5-(2-methyl-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}-2,5-difluorobenzenesulfonamide

HRID 212936Notes

Reaction equation

HRID 212936 reaction equation
[CH3:36][Zn:37][CH3:38].[CH3:39][c:40]1[cH:41][cH:42][cH:43][cH:44][cH:45]1.[Cl:1][c:2]1[c:3]([NH:24][S:25](=[O:26])(=[O:27])[c:28]2[c:29]([F:35])[cH:30][cH:31][c:32]([F:34])[cH:33]2)[cH:4][cH:5][cH:6][c:7]1-[c:8]1[n:9][c:10]([C:20]([CH3:21])([CH3:22])[CH3:23])[s:11][c:12]1-[c:13]1[n:14][c:15]([Cl:19])[n:16][cH:17][cH:18]1>>[Cl:1][c:2]1[c:3]([NH:24][S:25](=[O:26])(=[O:27])[c:28]2[c:29]([F:35])[cH:30][cH:31][c:32]([F:34])[cH:33]2)[cH:4][cH:5][cH:6][c:7]1-[c:8]1[n:9][c:10]([C:20]([CH3:21])([CH3:22])[CH3:23])[s:11][c:12]1-[c:13]1[n:14][c:15]([CH3:36])[n:16][cH:17][cH:18]1

Participants

4

Reactant 3

HCID 1140TolueneHCID 57989680N-{2-Chloro-3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]phenyl}-2,5-difluorobenzenesulfonamideHCID 178477796HCID 178477796, compound

Product 1

HCID 57989995N-{2-chloro-3-[2-(1,1-dimethylethyl)-5-(2-methyl-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}-2,5-difluorobenzenesulfonamide

Sources & evidence

ORD record
ord-910117be23104ff9a624acefa3a12fde
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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