HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-(3-Thiophenesulfonyloxy)-5-methoxy-7-iodoisoindolinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Thiophene-3-sulfonyl Chloride | HCID 2776378 | — |
| Reactant | 4-Hydroxy-5-methoxy-7-iodoisoindolinone | HCID 68489957 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-(3-Thiophenesulfonyloxy)-5-methoxy-7-iodoisoindolinone | HCID 86628313 | 81% |
Reaction Steps
In a similar manner to Step 1 of Example 227, 4-hydroxy-5-methoxy-7-iodoisoindolinone (0.265 g, 0.869 mmol) was dissolved in acetonitrile (8.0 mL), and the solution was treated with triethylamine (0.242 mL, 1.74 mmol) and 3-thiophenesulfonyl chloride (0.191 g, 1.04 mmol) to obtain 4-(3-thiophenesulfonyloxy)-5-methoxy-7-iodoisoindolinone (0.316 g, yield 81%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745641B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-a8fb8bddf16f4efbacc49b7ec5486280 |
| Source note | uspto-grants-2010_06 |