5-Bromo-2-thiophenesulfonamide → 5-[7-Cyclopropyl-5-(3,4-dichloro-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-thiophene-2-sulfonic acid amide

HRID 2129661Notes

Reaction equation

HRID 2129661 reaction equation
[Br:23][c:24]1[cH:25][cH:26][c:27]([S:29](=[O:30])(=[O:31])[NH2:32])[s:28]1.[CH:1]1([c:4]2[cH:5][c:6](-[c:15]3[cH:16][c:17]([Cl:22])[c:18]([Cl:21])[cH:19][cH:20]3)[n:7][c:8]3[n:9]2[n:10][cH:11][c:12]3[C:13]#[CH:14])[CH2:2][CH2:3]1>>[CH:1]1([c:4]2[cH:5][c:6](-[c:15]3[cH:16][c:17]([Cl:22])[c:18]([Cl:21])[cH:19][cH:20]3)[n:7][c:8]3[n:9]2[n:10][cH:11][c:12]3[C:13]#[C:14][c:24]2[cH:25][cH:26][c:27]([S:29](=[O:30])(=[O:31])[NH2:32])[s:28]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 12413045-Bromo-2-thiophenesulfonamideHCID 866080507-Cyclopropyl-5-(3,4-dichloro-phenyl)-3-ethynyl-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 670007205-[7-Cyclopropyl-5-(3,4-dichloro-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-thiophene-2-sulfonic acid amide

Sources & evidence

ORD record
ord-f5d97ff74f2340f59edb5f003a4c31d0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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