Acetic Acid → HCID 86628322, compound

Participants

Reaction Steps

In a similar manner to Step 2 of Example 6, 4-(2-pyridinesulfonyloxy)-5-methoxy-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone (0.318 g, 0.564 mmol) was dissolved in acetonitrile (10.0 mL), and the solution was treated with piperidine (1.10 mL, 11.3 mmol), acetic acid (0.646 mL, 11.3 mmol) and sodium triacetoxyborohydride (0.359 g, 1.69 mmol), followed by purification by flash column chromatography (chloroform/methanol=85/15) to obtain 4-(2-pyridinesulfonyloxy)-5-methoxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.126 g, 35%).

Provenance & Evidence