N-[[18-[2-[4-(isopropyl)thiazol-2-yl]-7-methoxyquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-en-4-yl]carbonyl](cyclopropyl)sulfonamide → N-[17-[8-chloro-2-(4-isopropylthiazol-2-yl)-7-methoxyquinolin-4-yloxy]-2,14-dioxo-3,15-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carbonyl]-(cyclopropyl)sulfonamide

HRID 2130302Notes

Reaction equation

HRID 2130302 reaction equation
[CH:46]([c:47]1[n:48][c:49](-[c:50]2[cH:51][c:52]([O:53][CH:54]3[CH2:55][CH:56]4[N:57]([C:58](=[O:59])[CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][CH2:65][CH:66]=[CH:67][CH:68]5[C:69]([C:70](=[O:71])[NH:87][S:88](=[O:89])(=[O:90])[CH:91]6[CH2:92][CH2:93]6)([NH:72][C:73]4=[O:74])[CH2:75]5)[CH2:76]3)[c:77]3[c:78]([cH:79][c:80]([O:81][CH3:82])[cH:83][cH:84]3)[n:85]2)[s:86][cH:94]1)([CH3:95])[CH3:96].[Cl:1][c:2]1[c:3]([O:44][CH3:45])[cH:4][cH:5][c:6]2[c:7]([O:20][CH:21]3[CH2:22][N:23]4[C:24](=[O:43])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH:30]=[CH:31][CH:32]5[CH2:33][C:34]5([C:40](=[O:41])[OH:42])[NH:35][C:36](=[O:39])[CH:37]4[CH2:38]3)[cH:8][c:9](-[c:12]3[s:13][cH:14][c:15]([CH:17]([CH3:18])[CH3:19])[n:16]3)[n:10][c:11]12>>[Cl:1][c:2]1[c:3]([O:44][CH3:45])[cH:4][cH:5][c:6]2[c:7]([O:20][CH:21]3[CH2:22][N:23]4[C:24](=[O:43])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH:30]=[CH:31][CH:32]5[CH2:33][C:34]5([C:40](=[O:42])[NH:87][S:88](=[O:89])(=[O:90])[CH:91]5[CH2:92][CH2:93]5)[NH:35][C:36](=[O:39])[CH:37]4[CH2:38]3)[cH:8][c:9](-[c:12]3[s:13][cH:14][c:15]([CH:17]([CH3:18])[CH3:19])[n:16]3)[n:10][c:11]12

Participants

3

Reactant 2

HCID 67318810N-[[18-[2-[4-(isopropyl)thiazol-2-yl]-7-methoxyquinolin-4-yloxy]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-en-4-yl]carbonyl](cyclopropyl)sulfonamideHCID 6731937617-[8-Chloro-2-(4-isopropylthiazol-2-yl)-7-methoxyquinolin-4-yloxy]-2,14-dioxo-3,15-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid

Product 1

HCID 67320301N-[17-[8-chloro-2-(4-isopropylthiazol-2-yl)-7-methoxyquinolin-4-yloxy]-2,14-dioxo-3,15-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carbonyl]-(cyclopropyl)sulfonamide

Sources & evidence

ORD record
ord-55258d46c6b54142852416cebd4fa738
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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