Bicarbonate Ion → 1-Boc-4-(3-trifluoromethyl-phenylamino)-piperidine

HRID 2130318Notes

Reaction equation

HRID 2130318 reaction equation
[C:26]([O:27][BH-:28]([O:29][C:30](=[O:31])[CH3:32])[O:33][C:34](=[O:35])[CH3:36])(=[O:37])[CH3:38].[F:15][C:16]([c:17]1[cH:18][c:19]([NH2:20])[cH:21][cH:22][cH:23]1)([F:24])[F:25].[Na+:39].[Na+:44].[O-:40][C:41]([OH:42])=[O:43].[O:1]=[C:2]1[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1>>[CH:2]1([NH:20][c:19]2[cH:18][c:17]([C:16]([F:15])([F:24])[F:25])[cH:23][cH:22][cH:21]2)[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1

Participants

6

Reactant 5

HCID 769Bicarbonate IonHCID 923Sodium ion2×HCID 73753-(Trifluoromethyl)anilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 2724942Triacetoxyborohydride

Product 1

HCID 37223301-Boc-4-(3-trifluoromethyl-phenylamino)-piperidine

Sources & evidence

ORD record
ord-18d07724fe83428581f164b4e0f666ff
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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