Methanol → racemic (2'S,3S,4'R)-6-chloro-2'-(3-chlorophenyl)-4'-(5-fluoro-2-methyl-phenyl)-spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

HRID 2130333Notes

Reaction equation

HRID 2130333 reaction equation
[CH2:1]([O:2][C:3](=[O:4])[N:6]1[C:7](=[O:37])[C:8]2([c:9]3[cH:10][cH:11][c:12]([Cl:15])[cH:13][c:14]31)[CH:16]([c:30]1[cH:31][c:32]([Cl:36])[cH:33][cH:34][cH:35]1)[NH:17][C:18](=[O:29])[CH2:19][CH:20]2[c:21]1[c:22]([CH3:28])[cH:23][cH:24][c:25]([F:27])[cH:26]1)[CH3:5].[CH3:40][OH:41].[Na+:39].[OH-:38]>>[NH:6]1[C:7](=[O:37])[C:8]2([c:9]3[cH:10][cH:11][c:12]([Cl:15])[cH:13][c:14]31)[CH:16]([c:30]1[cH:31][c:32]([Cl:36])[cH:33][cH:34][cH:35]1)[NH:17][C:18](=[O:29])[CH2:19][CH:20]2[c:21]1[c:22]([CH3:28])[cH:23][cH:24][c:25]([F:27])[cH:26]1

Participants

5

Reactant 4

HCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 76567933racemic (2'S,3S,4'R)-6-chloro-2'-(3-chlorophenyl)-4'-(5-fluoro-2-methyl-phenyl)-2,3-dihydro-2,6'-dioxo spiro[indole-3,3'-piperidine]-1-carboxylic acid ethyl ester

Product 1

HCID 76568090racemic (2'S,3S,4'R)-6-chloro-2'-(3-chlorophenyl)-4'-(5-fluoro-2-methyl-phenyl)-spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

Sources & evidence

ORD record
ord-a13b023b34cb48dfa20e0c27e640436a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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