HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 86628323, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Fluoro-4-methylbenzene-1-sulfonyl chloride | HCID 2778600 | — |
| Reactant | 4-Hydroxy-5-methoxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone | HCID 68493793 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 86628323 | HCID 86628323 | 27.2% |
Reaction Steps
In a similar manner to Step 1 of Example 227, 4-hydroxy-5-methoxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.188 g, 0.382 mmol) was dissolved in acetonitrile (8.0 mL), and the solution was treated with triethylamine (0.160 mL, 1.15 mmol) and 3-fluoro-4-methylbenzenesulfonyl chloride (0.120 mg, 0.574 mmol) to obtain 4-(3-fluoro-4-methylbenzenesulfonyloxy)-5-methoxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0690 g, yield 27%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745641B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-3cc9b3bfd56741858bc8eaf063b956e5 |
| Source note | uspto-grants-2010_06 |