Acetate → N-[6-[3-(phenylmethoxy)phenyl]-1-[[2-(trimethylsilyl)ethoxy]-methyl]-1H-indazol-3-yl]butanamide

HRID 2130519Notes

Reaction equation

HRID 2130519 reaction equation
[C:44]([O-:45])(=[O:46])[CH3:47].[C:49]([O-:50])(=[O:51])[CH3:52].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11]([B:15]([OH:16])[OH:17])[cH:12][cH:13][cH:14]1.[Cl:20][c:21]1[cH:22][cH:23][c:24]2[c:25]([NH:38][C:39]([CH2:40][CH2:41][CH3:42])=[O:43])[n:26][n:27]([CH2:30][O:31][CH2:32][CH2:33][Si:34]([CH3:35])([CH3:36])[CH3:37])[c:28]2[cH:29]1.[Cs+:19].[F-:18].[Pd+2:48]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11](-[c:21]2[cH:22][cH:23][c:24]3[c:25]([NH:38][C:39]([CH2:40][CH2:41][CH3:42])=[O:43])[n:26][n:27]([CH2:30][O:31][CH2:32][CH2:33][Si:34]([CH3:35])([CH3:36])[CH3:37])[c:28]3[cH:29]2)[cH:12][cH:13][cH:14]1

Participants

7

Reactant 6

HCID 175Acetate2×HCID 28179Fluoride IonHCID 104967Cesium cationHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 27343133-Benzyloxy-phenylboronic acidHCID 10406687N-[6-chloro-1-[[2-(trimethylsilyl)ethoxy)methyl]-1H-indazol-3-yl)butanamide

Product 1

HCID 22319536N-[6-[3-(phenylmethoxy)phenyl]-1-[[2-(trimethylsilyl)ethoxy]-methyl]-1H-indazol-3-yl]butanamide

Sources & evidence

ORD record
ord-0c711989fd77462c9d9d1fc233fbf2e0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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