2-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)nicotinamide → 2-(4-(2-Carbamoylpyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)nicotinamide

HRID 2130731Notes

Reaction equation

HRID 2130731 reaction equation
[NH2:1][c:2]1[cH:3][c:4]([F:18])[c:5]([O:6][c:7]2[cH:8][c:9]([C:13](=[O:14])[NH2:15])[n:10][cH:11][cH:12]2)[cH:16][cH:17]1.[nH:19]1[c:20]2[n:21][cH:22][cH:23][c:24]([O:25][c:26]3[cH:27][cH:28][c:29]([NH:30][c:36]4[c:37]([C:38](=[O:39])[NH:40][c:41]5[c:42]([F:48])[cH:43][c:44]([F:47])[cH:45][cH:46]5)[cH:49][cH:50][cH:51][n:52]4)[cH:31][c:32]3[F:33])[c:34]2[cH:35][cH:53]1>>[NH:1]([c:2]1[cH:3][c:4]([F:18])[c:5]([O:6][c:7]2[cH:8][c:9]([C:13](=[O:14])[NH2:15])[n:10][cH:11][cH:12]2)[cH:16][cH:17]1)[c:36]1[c:37]([C:38](=[O:39])[NH:40][c:41]2[c:42]([F:48])[cH:43][c:44]([F:47])[cH:45][cH:46]2)[cH:49][cH:50][cH:51][n:52]1

Participants

3

Reactant 2

HCID 162230082-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)nicotinamideHCID 231532054-(4-Amino-2-fluorophenoxy)picolinamide

Product 1

HCID 577213642-(4-(2-Carbamoylpyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)nicotinamide

Sources & evidence

ORD record
ord-5820b1b8a93f42efad05fefe1519d5ff
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

Loading…