3-(Chloromethyl)-5-methyl-1,2-oxazole → N-Methyl-N-(2-{[4-({3-methyl-4-[(5-methylisoxazol-3-yl)methoxy]phenyl}amino) quinazolin-5-yl]oxy}ethyl)acetamide

HRID 2130988Notes

Reaction equation

HRID 2130988 reaction equation
[Cl:1][CH2:2][c:3]1[n:4][o:5][c:6]([CH3:8])[cH:7]1.[OH:9][c:10]1[c:11]([CH3:35])[cH:12][c:13]([NH:16][c:17]2[n:18][cH:19][n:20][c:21]3[cH:22][cH:23][cH:24][c:25]([O:27][CH2:28][CH2:29][N:30]([C:31]([CH3:32])=[O:33])[CH3:34])[c:26]23)[cH:14][cH:15]1>>[CH2:2]([c:3]1[n:4][o:5][c:6]([CH3:8])[cH:7]1)[O:9][c:10]1[c:11]([CH3:35])[cH:12][c:13]([NH:16][c:17]2[n:18][cH:19][n:20][c:21]3[cH:22][cH:23][cH:24][c:25]([O:27][CH2:28][CH2:29][N:30]([C:31]([CH3:32])=[O:33])[CH3:34])[c:26]23)[cH:14][cH:15]1

Participants

3

Reactant 2

HCID 27357633-(Chloromethyl)-5-methyl-1,2-oxazoleHCID 69059574N-[2-({4-[(4-hydroxy-3-methylphenyl)amino]quinazolin-5-yl}oxy)ethyl]-N-methylacetamide

Product 1

HCID 11442573N-Methyl-N-(2-{[4-({3-methyl-4-[(5-methylisoxazol-3-yl)methoxy]phenyl}amino) quinazolin-5-yl]oxy}ethyl)acetamide

Sources & evidence

ORD record
ord-3e8903b1b9784d368955552507037f4d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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