Dichloromethane → rac-(2R,3S,4R,5S)-4-(4-Chloro-2-fluoro-phenyl)-3-(3-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carboxylic acid [4-(methanesulfonylamino-methyl)-phenyl]-amide
Reaction equation
[CH3:40][S:41](=[O:42])(=[O:43])[Cl:44].[Cl:45][CH2:46][Cl:47].[NH2:1][CH2:2][c:3]1[cH:4][cH:5][c:6]([NH:9][C:10](=[O:11])[CH:12]2[NH:13][CH:14]([CH2:35][C:36]([CH3:37])([CH3:38])[CH3:39])[C:15]([C:25]#[N:26])([c:27]3[c:28]([F:34])[cH:29][c:30]([Cl:33])[cH:31][cH:32]3)[CH:16]2[c:17]2[c:18]([F:24])[c:19]([Cl:23])[cH:20][cH:21][cH:22]2)[cH:7][cH:8]1>>[NH:1]([CH2:2][c:3]1[cH:4][cH:5][c:6]([NH:9][C:10](=[O:11])[CH:12]2[NH:13][CH:14]([CH2:35][C:36]([CH3:37])([CH3:38])[CH3:39])[C:15]([C:25]#[N:26])([c:27]3[c:28]([F:34])[cH:29][c:30]([Cl:33])[cH:31][cH:32]3)[CH:16]2[c:17]2[c:18]([F:24])[c:19]([Cl:23])[cH:20][cH:21][cH:22]2)[cH:7][cH:8]1)[S:41]([CH3:40])(=[O:42])=[O:43]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-85036bbd90394fe3974317d47429e380
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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