Diisopropyl Ether → 4-Chloro-5-(3-aminopropoxy)-7-iodoisoindolinone hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	Diisopropyl Ether	HCID 7914	—
Reactant	Hydrochloride methanol	HCID 21893726	—
Reactant	Carbamic acid,[3-[(4-chloro-2,3-dihydro-7-iodo-1-oxo-1h-isoindol-5-yl)oxy]propyl]-,1,1-dimethylethyl ester	HCID 68489177	—
Solvent	Methanol	HCID 887	—
Product	4-Chloro-5-(3-aminopropoxy)-7-iodoisoindolinone hydrochloride	HCID 68488409	193%

Reaction Conditions

Temperature	60 °C

Reaction Steps

4-Chloro-5-[3-(tert-butoxycarbonylamino)propoxy]-7-iodoisoindolinone (101 mg, 0.216 mmol) was suspended in methanol (1.5 mL), and the suspension was added with 10% hydrogen chloride-methanol solution (1.5 mL), followed by stirring at 60° C. for 1.0 hour. The reaction mixture was added with diisopropylether. The obtained solid was collected by filtration and washed with diisopropylether, followed by drying under reduced pressure to obtain 4-chloro-5-(3-aminopropoxy)-7-iodoisoindolinone hydrochloride (84.0 mg, yield 96%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07745641B2
Source dataset	uspto-grants-2010_06
ORD ID	ord-59d850f02eb147a4a9f8d896a69cdd5b
Source note	uspto-grants-2010_06