Potassium Cation → 4-Amino-3'-benzyloxy-3-cyano-6-fluoro-5-methoxy-2-methylbiphenyl

HRID 2132465Notes

Reaction equation

HRID 2132465 reaction equation
[C:1](=[O:2])([O-:3])[O-:4].[CH2:7]([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[O:14][c:15]1[cH:16][c:17](-[c:21]2[c:22]([F:39])[c:23]([O:37][CH3:38])[c:24]([NH:30][C:31](=[O:32])[C:33]([F:34])([F:35])[F:36])[c:25]([C:28]#[N:29])[c:26]2[CH3:27])[cH:18][cH:19][cH:20]1.[CH3:40][OH:41].[K+:5].[K+:6]>>[CH2:7]([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[O:14][c:15]1[cH:16][c:17](-[c:21]2[c:22]([F:39])[c:23]([O:37][CH3:38])[c:24]([NH2:30])[c:25]([C:28]#[N:29])[c:26]2[CH3:27])[cH:18][cH:19][cH:20]1

Participants

5

Reactant 4

HCID 813Potassium Cation2×HCID 887MethanolHCID 19660Carbonate IonHCID 86630821N-(3'-Benzyloxy-5-cyano-2-fluoro-3-methoxy-6-methylbiphenyl-4-yl)-2,2,2-trifluoroacetamide

Product 1

HCID 866308224-Amino-3'-benzyloxy-3-cyano-6-fluoro-5-methoxy-2-methylbiphenyl

Sources & evidence

ORD record
ord-88d863a060664c948ae52e2ffc6c6129
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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