4-Chloropyridine-2-carboxamide → 4-(4-Amino-2,6-difluorophenoxy)picolinamide

HRID 213291Notes

Reaction equation

HRID 213291 reaction equation
[CH3:11][O:12][c:13]1[cH:14][cH:15][c:16]([CH2:17][NH:18][c:19]2[n:20][c:21]([O:22][c:23]3[cH:24][cH:25][c:26]([NH:27][C:28](=[O:29])[CH2:30][C:31]([NH:32][c:33]4[cH:34][cH:35][c:36]([F:37])[cH:38][cH:39]4)=[O:40])[cH:41][c:42]3[F:43])[cH:44][cH:45][n:46]2)[cH:47][cH:48]1.[Cl:1][c:2]1[cH:3][c:4]([C:8](=[O:9])[NH2:10])[n:5][cH:6][cH:7]1.[NH2:49][c:50]1[cH:51][c:52]([F:58])[c:53]([OH:57])[c:54]([F:56])[cH:55]1>>[c:2]1([O:57][c:53]2[c:52]([F:58])[cH:51][c:50]([NH2:49])[cH:55][c:54]2[F:56])[cH:3][c:4]([C:8](=[O:9])[NH2:10])[n:5][cH:6][cH:7]1

Participants

4

Reactant 3

HCID 3035434-Chloropyridine-2-carboxamideHCID 27787644-Amino-2,6-difluorophenolHCID 59852883N1-(4-(2-(4-Methoxybenzylamino)pyrimidin-4-yloxy)-3-fluorophenyl)-N3-(4-fluorophenyl)malonamide

Product 1

HCID 598528534-(4-Amino-2,6-difluorophenoxy)picolinamide

Sources & evidence

ORD record
ord-13fe5c5ff3b845cdbe665993279306bc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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