Acetone → 1-Bromo-2-(difluoromethoxy)-4-fluorobenzene

HRID 2133586Notes

Reaction equation

HRID 2133586 reaction equation
[Br:10][C:11]([C:12]([O:13][CH2:14][CH3:15])=[O:16])([F:17])[F:18].[Br:1][c:2]1[c:3]([OH:9])[cH:4][c:5]([F:8])[cH:6][cH:7]1.[C:19](=[O:20])([O-:21])[O-:22].[CH3:25][C:26](=[O:27])[CH3:28].[K+:23].[K+:24]>>[Br:1][c:2]1[c:3]([O:9][CH:11]([F:17])[F:18])[cH:4][c:5]([F:8])[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 180AcetoneHCID 813Potassium Cation2×HCID 19660Carbonate IonHCID 69585Ethyl bromodifluoroacetateHCID 27246002-Bromo-5-fluorophenol

Product 1

HCID 451587111-Bromo-2-(difluoromethoxy)-4-fluorobenzene

Sources & evidence

ORD record
ord-7d4c04bb52634624b33a4f25a601f7fc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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