Ethyl trans-4-(7-amino-2-methyl-1-oxo-2,3-dihydro-1H-isoindol-4-yl)cyclohexanecarboxylate → Ethyl cis-4-(7-{[2-({4-[(diethoxyphosphoryl)methyl]-2-ethoxyphenyl}amino)-5-(trifluoromethyl)pyrimidin-4-yl]amino}-2-methyl-1-oxo-2,3-dihydro-1H-isoindol-4-yl)cyclohexanecarboxylate
Reaction equation
[Cl:1][c:2]1[n:3][c:4]([NH:12][c:13]2[c:14]([O:28][CH2:29][CH3:30])[cH:15][c:16]([CH2:17][P:18]([O:19][CH2:20][CH3:21])([O:22][CH2:23][CH3:24])=[O:25])[cH:26][cH:27]2)[n:5][cH:6][c:7]1[C:8]([F:9])([F:10])[F:11].[NH2:31][c:32]1[cH:33][cH:34][c:35]([CH:43]2[CH2:44][CH2:45][CH:46]([C:49](=[O:50])[O:51][CH2:52][CH3:53])[CH2:47][CH2:48]2)[c:36]2[c:40]1[C:39](=[O:41])[N:38]([CH3:42])[CH2:37]2>>[c:2]1([NH:31][c:32]2[cH:33][cH:34][c:35]([CH:43]3[CH2:44][CH2:45][CH:46]([C:49](=[O:50])[O:51][CH2:52][CH3:53])[CH2:47][CH2:48]3)[c:36]3[c:40]2[C:39](=[O:41])[N:38]([CH3:42])[CH2:37]3)[n:3][c:4]([NH:12][c:13]2[c:14]([O:28][CH2:29][CH3:30])[cH:15][c:16]([CH2:17][P:18]([O:19][CH2:20][CH3:21])([O:22][CH2:23][CH3:24])=[O:25])[cH:26][cH:27]2)[n:5][cH:6][c:7]1[C:8]([F:9])([F:10])[F:11]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-3277bf0f60ff42f3ba7c7b9e822ab689
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
Loading…