3-Pyridinemethanamine → 2-(3-(isoquinolin-1-ylmethyl)-2-oxoimidazolidin-1-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide

HRID 2134016Notes

Reaction equation

HRID 2134016 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]2[s:6][cH:7][c:8]([CH2:9][N:10]3[CH2:11][CH2:12][N:13]([c:14]4[s:15][c:16]([C:17]([OH:18])=[O:19])[c:20]([CH3:21])[n:22]4)[C:23]3=[O:24])[c:25]2[cH:26]1.[NH2:53][CH2:54][c:55]1[cH:56][n:57][cH:58][cH:59][cH:60]1.[c:27]1([CH2:37][N:38]2[C:39](=[O:52])[N:40]([c:43]3[s:44][c:45]([C:49](=[O:50])[OH:51])[c:46]([CH3:48])[n:47]3)[CH2:41][CH2:42]2)[n:28][cH:29][cH:30][c:31]2[cH:32][cH:33][cH:34][cH:35][c:36]12>>[c:27]1([CH2:37][N:38]2[C:39](=[O:52])[N:40]([c:43]3[s:44][c:45]([C:49](=[O:51])[NH:53][CH2:54][c:55]4[cH:56][n:57][cH:58][cH:59][cH:60]4)[c:46]([CH3:48])[n:47]3)[CH2:41][CH2:42]2)[n:28][cH:29][cH:30][c:31]2[cH:32][cH:33][cH:34][cH:35][c:36]12

Participants

4

Reactant 3

HCID 310183-PyridinemethanamineHCID 580314282-(3-(Isoquinolin-1-ylmethyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acidHCID 580315052-(3-((5-Chlorobenzo[b]thiophen-3-yl)methyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acid

Product 1

HCID 250969372-(3-(isoquinolin-1-ylmethyl)-2-oxoimidazolidin-1-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide

Sources & evidence

ORD record
ord-ca2415a396654f109cbfdc00e3dec0cd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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