Methyl 2-(5-bromopyridin-3-yl)acetate → [5-(2-Formyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid methyl ester

HRID 2134053Notes

Reaction equation

HRID 2134053 reaction equation
[CH3:1][C:2]1([CH3:3])[C:4]([CH3:5])([CH3:6])[O:7][B:8]([c:9]2[c:10]([CH:11]=[O:12])[cH:13][c:14]([C:17]([F:18])([F:19])[F:20])[cH:15][cH:16]2)[O:21]1.[CH3:22][O:23][C:24]([CH2:25][c:26]1[cH:27][n:28][cH:29][c:30]([Br:32])[cH:31]1)=[O:33]>>[c:9]1(-[c:30]2[cH:29][n:28][cH:27][c:26]([CH2:25][C:24]([O:23][CH3:22])=[O:33])[cH:31]2)[c:10]([CH:11]=[O:12])[cH:13][c:14]([C:17]([F:18])([F:19])[F:20])[cH:15][cH:16]1

Participants

3

Reactant 2

HCID 23398394Methyl 2-(5-bromopyridin-3-yl)acetateHCID 866405342-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)benzaldehyde

Product 1

HCID 86640539[5-(2-Formyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid methyl ester

Sources & evidence

ORD record
ord-e712c4d5e3564bc8bc56fd82f4565df6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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