Potassium Cation → 4,4-Dimethyl-2-[4-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-oxazole

HRID 213658Notes

Reaction equation

HRID 213658 reaction equation
[K+:25].[OH-:24].[OH:1][CH2:2][C:3]([CH3:4])([CH3:5])[NH:6][C:7]([c:8]1[cH:9][cH:10][c:11]([O:14][C:15]([F:16])([F:17])[F:18])[cH:12][cH:13]1)=[O:19].[S:20]([Cl:21])([Cl:22])=[O:23]>>[CH2:2]1[C:3]([CH3:4])([CH3:5])[N:6]=[C:7]([c:8]2[cH:9][cH:10][c:11]([O:14][C:15]([F:16])([F:17])[F:18])[cH:12][cH:13]2)[O:19]1

Participants

5

Reactant 4

HCID 813Potassium CationHCID 961HydroxideHCID 24386Thionyl ChlorideHCID 43390602N-(2-hydroxy-1,1-dimethylethyl)-4-(trifluoromethoxy)benzamide

Product 1

HCID 594471824,4-Dimethyl-2-[4-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-oxazole

Sources & evidence

ORD record
ord-f3c8f2af43e84896804db0fbdbc09a99
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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