HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-(3-Cyano-4,5,6,7-tetrahydrobenzo(b)thien-2-yl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | 2-Amino-4,5,6,7-tetrahydrobenzo(b)thiophene-3-carbonitrile | HCID 78382 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-(3-Cyano-4,5,6,7-tetrahydrobenzo(b)thien-2-yl)benzamide | HCID 290221 | 97% |
Reaction Steps
4.7 ml (40 mmol) of benzoyl chloride were added to a solution of 5.34 g (30 mmol) of 2-amino-3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene in 50 ml of pyridine. Stirring was carried out for 2 hours at 80° C. after which 150 ml of 10 mol % aqueous hydrochloric acid were added to the mixture. The solid formed was isolated in a conventional manner. Yield: 97%; mp.: 168°-170° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05422335 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-c687d545fb614a2799fe1a2c2fe90189 |
| Source note | uspto-grants-1995_06 |