4-Bromothiophene-2-carbonitrile → 4-(4,4-Dicyclopropyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]oxazin-6-yl)-thiophene-2-carbonitrile

HRID 2136990Notes

Reaction equation

HRID 2136990 reaction equation
[Br:21][c:22]1[cH:23][c:24]([C:27]#[N:28])[s:25][cH:26]1.[CH:1]1([C:4]2([CH:18]3[CH2:19][CH2:20]3)[O:5][C:6](=[O:17])[NH:7][c:8]3[c:9]2[cH:10][c:11]([B:14]([OH:15])[OH:16])[cH:12][cH:13]3)[CH2:2][CH2:3]1>>[CH:1]1([C:4]2([CH:18]3[CH2:19][CH2:20]3)[O:5][C:6](=[O:17])[NH:7][c:8]3[c:9]2[cH:10][c:11](-[c:22]2[cH:23][c:24]([C:27]#[N:28])[s:25][cH:26]2)[cH:12][cH:13]3)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 142923554-Bromothiophene-2-carbonitrileHCID 23509592(4,4-dicyclopropyl-1,4-dihydro-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid

Product 1

HCID 98808904-(4,4-Dicyclopropyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]oxazin-6-yl)-thiophene-2-carbonitrile

Sources & evidence

ORD record
ord-ce7012e56bc3418ba2336461ee219764
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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