Dichloromethane → 2-Chloro-4-(cyclopropyl(fluoro)methyl)pyrimidine

HRID 2137127Notes

Reaction equation

HRID 2137127 reaction equation
[CH2:13]([N:14]([S:15]([F:16])([F:17])[F:19])[CH2:18][CH3:20])[CH3:21].[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([CH:8]([OH:9])[CH:10]2[CH2:11][CH2:12]2)[n:7]1.[Cl:22][CH2:23][Cl:24]>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([CH:8]([CH:10]2[CH2:11][CH2:12]2)[F:19])[n:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 123472(Diethylamino)sulfur trifluorideHCID 77231063(2-Chloropyrimidin-4-yl)(cyclopropyl)methanol

Product 1

HCID 866582382-Chloro-4-(cyclopropyl(fluoro)methyl)pyrimidine

Sources & evidence

ORD record
ord-378a7b19d9a348d0ae05c58631229162
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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