5-Bromo-1-benzothiophene → 4-(5-Bromobenzo[b]thiophen-2-yl)-2-methyl-1,2,3,4-tetrahydroisoquinoline-4-ol

HRID 2137533Notes

Reaction equation

HRID 2137533 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:7][cH:8][s:9]2)[cH:10]1.[C:11]([Li:12])([CH3:13])([CH3:14])[CH3:15].[CH3:16][N:17]1[CH2:18][c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]2[C:25](=[O:27])[CH2:26]1>>[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:7][c:8]([C:25]3([OH:27])[c:24]4[c:19]([cH:20][cH:21][cH:22][cH:23]4)[CH2:18][N:17]([CH3:16])[CH2:26]3)[s:9]2)[cH:10]1

Participants

4

Reactant 3

HCID 27765785-Bromo-1-benzothiopheneHCID 106308122-Methyl-2,3-dihydroisoquinolin-4(1H)-oneHCID 178418306HCID 178418306, compound

Product 1

HCID 689934704-(5-Bromobenzo[b]thiophen-2-yl)-2-methyl-1,2,3,4-tetrahydroisoquinoline-4-ol

Sources & evidence

ORD record
ord-dfdc5a65c5a84bc9a56e9a2d92f27a1a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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