5,7-Difluoro-2-tetralone → 2-(5,7-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid [1-(1,1-dimethyl-2-pyrrolidin-1-yl-ethyl)-1H-imidazol-4-yl]-amide

HRID 213827Notes

Reaction equation

HRID 213827 reaction equation
[CH3:1][C:2]([CH2:3][N:4]1[CH2:5][CH2:6][CH2:7][CH2:8]1)([CH3:9])[n:10]1[cH:11][n:12][c:13]([NH:15][C:16]([CH:17]([CH2:18][CH2:19][CH3:20])[NH2:21])=[O:22])[cH:14]1.[F:23][c:24]1[c:25]2[c:30]([cH:31][c:32]([F:34])[cH:33]1)[CH2:29][C:28](=[O:35])[CH2:27][CH2:26]2>>[CH3:1][C:2]([CH2:3][N:4]1[CH2:5][CH2:6][CH2:7][CH2:8]1)([CH3:9])[n:10]1[cH:11][n:12][c:13]([NH:15][C:16]([CH:17]([CH2:18][CH2:19][CH3:20])[NH:21][CH:28]2[CH2:27][CH2:26][c:25]3[c:24]([F:23])[cH:33][c:32]([F:34])[cH:31][c:30]3[CH2:29]2)=[O:22])[cH:14]1

Participants

3

Reactant 2

HCID 36357585,7-Difluoro-2-tetraloneHCID 671642262-Amino-pentanoic acid [1-(1,1-dimethyl-2-pyrrolidin-1-yl-ethyl)-1H-imidazol-4-yl]-amide

Product 1

HCID 116485382-(5,7-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid [1-(1,1-dimethyl-2-pyrrolidin-1-yl-ethyl)-1H-imidazol-4-yl]-amide

Sources & evidence

ORD record
ord-b6ba74bb5fb649d6be944ba458b5246d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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