2-(Methylsulfanyl)pyrimidin-5-ol → 4-[4-(2-Methylsulfanyl-pyrimidin-5-yloxymethyl)-thiazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

HRID 2138379Notes

Reaction equation

HRID 2138379 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[s:15][cH:16][c:17]([CH2:19][Cl:20])[n:18]2)[CH2:12][CH2:13]1.[CH3:21][S:22][c:23]1[n:24][cH:25][c:26]([OH:29])[cH:27][n:28]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[s:15][cH:16][c:17]([CH2:19][O:29][c:26]3[cH:25][n:24][c:23]([S:22][CH3:21])[n:28][cH:27]3)[n:18]2)[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 5883572-(Methylsulfanyl)pyrimidin-5-olHCID 57423790Tert-butyl 4-[4-(chloromethyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate

Product 1

HCID 579868064-[4-(2-Methylsulfanyl-pyrimidin-5-yloxymethyl)-thiazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-b8bd93e1df8b45768f1f179eb3ab7398
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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