Acetic Acid → 1-Boc-4-[(3,4-dichlorophenyl)amino]-piperidine

HRID 2138859Notes

Reaction equation

HRID 2138859 reaction equation
[C:10]([CH3:11])([CH3:12])([CH3:13])[O:14][C:15](=[O:16])[N:17]1[CH2:18][CH2:19][C:20](=[O:23])[CH2:21][CH2:22]1.[C:24]([O:25][BH-:26]([O:27][C:28](=[O:29])[CH3:30])[O:31][C:32](=[O:33])[CH3:34])(=[O:35])[CH3:36].[CH3:44][C:45](=[O:46])[OH:47].[Cl:40][CH:41]([Cl:42])[CH3:43].[NH2:1][c:2]1[cH:3][cH:4][c:5]([Cl:6])[c:7]([Cl:8])[cH:9]1.[Na+:37].[Na+:39].[OH-:38]>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([Cl:6])[c:7]([Cl:8])[cH:9]1)[CH:20]1[CH2:19][CH2:18][N:17]([C:15]([O:14][C:10]([CH3:11])([CH3:12])[CH3:13])=[O:16])[CH2:22][CH2:21]1

Participants

8

Reactant 7

HCID 176Acetic AcidHCID 923Sodium ion2×HCID 961HydroxideHCID 63651,1-DichloroethaneHCID 72573,4-DichloroanilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 2724942Triacetoxyborohydride

Product 1

HCID 223224131-Boc-4-[(3,4-dichlorophenyl)amino]-piperidine

Sources & evidence

ORD record
ord-5590b315ea4040bba59036a909c59895
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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